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Archive for the ‘Medical Breakthroughs’ Category

Nivolumab Approved

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FDA Approves Nivolumab for Advanced Melanoma
OncLive – author: Silas Inman
The FDA has approved the PD-1 inhibitor nivolumab (Opdivo) for patients with metastatic melanoma following treatment with ipilimumab or a BRAF inhibitor, based on data from the phase III CheckMate-037 trial.… Read the rest

TAK-733 Next Gen-Melanoma Drug

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Next-Gen Melanoma Drug, TAK-733, Excels in Lab Tests

By Garth Sundem in the Lab – November 11, 2014 ·

A University of Colorado Cancer Center study published online this week in the journal Molecular Cancer Therapeutics reports anti-cancer activity in 10 out of 11 patient tumor samples grown in mice and treated with the experimental drug TAK-733, a small molecule inhibitor of MEK1/2.… Read the rest

John Hopkins Medicine

More Arrows in the Arsenal
By David Glenn
Illustration by Traci Daberko | Photos by Justin Tsucalas
Dramatic advances in immunotherapy offer new options for patients with advanced melanoma—and could even make chemotherapy a thing of the past.
As with many other cancers, metastatic melanoma cells have dozens of wicked capacities.… Read the rest

Immune Therapy’s Promise

Melanoma Breakthroughs 2014: A new class of medicines that help the body’s own immune cells fight tumors could target a wide set of cancers, opening a $35 billion market for Merck (MRK) & Co., Bristol-Myers Squibb Co., AstraZeneca Plc and Roche (ROG) Holding AG.… Read the rest

Melanoma Risk Assessment

Sun exposure, family history guide risk assessment for melanoma screening
April 14, 2014

NEW YORK — Several factors can help better define individuals at high risk for melanoma, according to a presenter at the HemOnc Today Melanoma and Cutaneous Malignancies meeting.… Read the rest

New Therapies Raise Hope

Washington Post: (February 17, 2014)
New therapies raise hope for a breakthrough in tackling cancer

By Arthur Allen, Published: February 17 E-mail the writer


In the summer of 2012, a year after his wife had died of lung cancer, Michael Harris scraped open an old mole on his back and it would not stop bleeding.… Read the rest

Hope for patients w/advanced

New therapies giving hope for patients with advanced melanoma
DENVER, Colo. (March 21, 2014) —Cutting-edge treatments represent recent surge in research aimed at battling melanoma

Although melanoma — the deadliest form of skin cancer — accounts for less than 5 percent of skin cancer cases, it is responsible for about 75 percent of all skin cancer deaths.¹ When melanoma is detected early and treated before it spreads to the lymph nodes, the five-year survival rate is approximately 98 percent.¹ However, when the disease spreads, the five-year survival rate drops considerably — to 62 percent in patients whose melanoma has spread to the lymph nodes and only 16 percent in patients whose melanoma has spread to other organs.¹
Within the last three years, significant progress has been made in treating advanced melanoma when the disease has spread beyond the skin.… Read the rest

Vemurafenib Comination Effective in Advanced BRAF-Mutant Melanoma

Encouraging Data:
OncLive: Silas Inman
Published Online: Wednesday, May 7, 201
The combination of the BRAF inhibitor vemurafenib (Zelboraf) with the investigational MEK inhibitor cobimetinib (GDC-0973) demonstrated a 13.7-month median progression-free survival (PFS) and an overall response rate (ORR) of 87% in treatment-naïve patients with BRAFV600 mutation-positive metastatic melanoma, according to phase Ib results presented at the 10th European Association of Dermato Oncology Congress in Vilnius, Lithuania.… Read the rest

Ipilimumab std of care

Ipilimumab may become standard of care for adjuvant melanoma therapy
April 11, 2014
 NEW YORK — Ipilimumab will replace interferon as the standard of care for adjuvant therapy of melanoma, but key questions remain about appropriate patient selection and dosing, according to a presenter at the HemOnc Today Melanoma and Cutaneous Malignancies meeting.
 … Read the rest

Immune Boost

Cancer treatment: The killer within
The immune system can be a powerful weapon against cancer — but researchers are still grappling with how to control it.
Article written by:  Heidi Ledford 02 April 2014
 The first tumour was a small melanoma on the left side of attorney Mark Gorman’s neck.… Read the rest