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Archive for the ‘Medical Breakthroughs’ Category

Genetic Factors

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Key Genetic Factor Controls Mole Development Into Melanoma

Researchers at the University of Pennsylvania and the Wistar Institute recently discovered a key genetic factor that maintains skin moles in a non-cancerous, no-growth state. The study was published in the journal Cancer Discovery and is entitled “CDKN2B loss promotes progression from benign melanocytic nevus to melanoma”.… Read the rest

Opdivo Approval

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What Cancer Patients Need to Know About the Opdivo (nivolumab) Approval
CANCER RESEARCH INSTITUTE: March 13, 2015 | Emily Helck

Now that Opdivo (nivolumab) has been FDA approved for two cancer types, and potentially more in the coming months, many patients are wondering: what’s next?… Read the rest

Immune Therapies

New Immunotherapy Drugs:  How They Work

WebMD: October, 2014. By Richard C. Frank, MD

Turning a patient’s own immune system against their cancer has long been considered the Holy Grail of cancer therapy.
For hundreds of years scientists, physicians, herbalists, and many, many non-scientists have endeavored to accomplish this.… Read the rest

Targeted therapy: Wistar Institute

Could the “Pac Man” of White Blood Cells Play an Important Role in Melanoma?
March 20, 2015
Posted by Ben Leach

Russel E. Kaufman, M.D.

While a few new drugs have been approved in recent years for melanoma, often times patients who receive them quickly become resistant and the treatment no longer works.… Read the rest

Nivolumab Approved

FDA Approves Nivolumab for Advanced Melanoma
OncLive – author: Silas Inman
The FDA has approved the PD-1 inhibitor nivolumab (Opdivo) for patients with metastatic melanoma following treatment with ipilimumab or a BRAF inhibitor, based on data from the phase III CheckMate-037 trial.… Read the rest

TAK-733 Next Gen-Melanoma Drug

Next-Gen Melanoma Drug, TAK-733, Excels in Lab Tests

By Garth Sundem in the Lab – November 11, 2014 ·

A University of Colorado Cancer Center study published online this week in the journal Molecular Cancer Therapeutics reports anti-cancer activity in 10 out of 11 patient tumor samples grown in mice and treated with the experimental drug TAK-733, a small molecule inhibitor of MEK1/2.… Read the rest

John Hopkins Medicine

More Arrows in the Arsenal
By David Glenn
Illustration by Traci Daberko | Photos by Justin Tsucalas
Dramatic advances in immunotherapy offer new options for patients with advanced melanoma—and could even make chemotherapy a thing of the past.
As with many other cancers, metastatic melanoma cells have dozens of wicked capacities.… Read the rest

Immune Therapy’s Promise

Melanoma Breakthroughs 2014: A new class of medicines that help the body’s own immune cells fight tumors could target a wide set of cancers, opening a $35 billion market for Merck (MRK) & Co., Bristol-Myers Squibb Co., AstraZeneca Plc and Roche (ROG) Holding AG.… Read the rest

Melanoma Risk Assessment

Sun exposure, family history guide risk assessment for melanoma screening
April 14, 2014

NEW YORK — Several factors can help better define individuals at high risk for melanoma, according to a presenter at the HemOnc Today Melanoma and Cutaneous Malignancies meeting.… Read the rest

New Therapies Raise Hope

Washington Post: (February 17, 2014)
New therapies raise hope for a breakthrough in tackling cancer

By Arthur Allen, Published: February 17 E-mail the writer


In the summer of 2012, a year after his wife had died of lung cancer, Michael Harris scraped open an old mole on his back and it would not stop bleeding.… Read the rest